“I want them to play big this weekend,” England head coach Steve Borthwick told BBC Sport.
“New Zealand has a formidable record at this venue, but with that comes the pressure of expectation.
“It will be interesting to see how New Zealand manages that expectation in front of a full house.”
Also among the replacements is Dan Cole, who will move up to second in the list of England’s most-capped male players if he comes off the bench to win his 115th cap.
The Leicester prop is currently level with 2003 World Cup-winner Jason Leonard, with scrum-half Ben Youngs leading the way on 127 caps.
“Dan has shown nothing but dedication and determination throughout his career, and reaching this milestone is a remarkable feat,” added Borthwick.
“He is a superb rugby player, a wonderful role model, and we all look forward to sharing a memorable day with him on Saturday.”
