Murray came through the Crusaders academy in New Zealand and played for Canterbury in the domestic competition before arriving in Wales.
He linked up with Scarlets this summer and has played just six games for his new side but impressed Gatland, as he was named as only one of two uncapped players in the 35-man squad alongside Gloucester lock Freddie Thomas.
Murray, who has has been preferred to Rio Dyer and Tom Rogers, lines up in a back three alongside full-back Cameron Winnett and Mason Grady, who switches to the wing from the inside centre role he occupied in the summer.
It is the first time Dyer has not started a Test match since the World Cup quarter-final defeat against Argentina in October 2023.
Anscombe, 33, will play his first Test for more than a year after missing last season because of a groin injury.
Thomas featured at fly-half in the two losing Tests in Australia but switches to his more familiar inside centre role as Wales try out yet another centre combination.
It will be Thomas’ first international start in the Wales number 12 jersey.
